NAD+ Storage, Stability & COA Guide

NAD+ (nicotinamide adenine dinucleotide) is not a peptide, but it sits on the same research-supply shelf — and it is one of the least stable materials there. Storage discipline matters more for NAD+ than for almost anything else you'll order.

Stability profile

NAD+ in solid form is hygroscopic and sensitive to heat, light, and moisture. Store lyophilized/powder material at −20°C, protected from light, with the container tightly sealed and allowed to reach room temperature before opening (to prevent condensation on the material). In aqueous solution NAD+ degrades quickly — solutions should be made fresh, kept cold, and used promptly; degradation products include nicotinamide, which changes what's actually in your vial.

What the COA should show

Identity (typically by mass spec or NMR; NAD+ has a molecular weight of 663.4 g/mol), purity by HPLC (research-grade material is typically ≥98%), water content where stated (hygroscopic materials pick up mass), the lot number matching your container, and a named third-party lab with a test date. Because NAD+ degrades in storage, a recent test date carries real information — an undated certificate on an unstable molecule is close to worthless.

Run any certificate through the free COA checker, and see how to read a COA for the general method.

Practical handling summary

Cold, dark, dry, sealed. −20°C for storage, minimal time at room temperature, fresh solutions only. If material arrives clumped, discolored, or with a strong odor, check it against the lot's COA before committing it to any work.